With project goals of allowing for Good Clinical Laboratory Practice (GCLP) workflows and meeting Clinical Laboratory Improvement Amendments (CLIA) standards, Hasenstab Architects designed a new Genomics Laboratory at Case Western Reserve University’s School of Medicine. The 1,600-square foot lab, which is located in the HG Wood Building, provides a wide range of genomics services, including genome sequencing, RNA-Seq, genotyping and epigenetics. In addition to an open lab area with bench space and built-in workstations, the project also includes faculty offices, staff work areas and a (Pre-PCR) workroom. The renovation was completed in two phases with demolition of the proposed project area first to allow for discovery of unknowns prior to design.